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Nac causing depression reddit?
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Nac causing depression reddit?
justretardedmonkey ago. I've been on for 3 months but really don't see a difference in that category ilmjdli Alright now am gonna share with you some supplements here and experience and my opinion, i really hope you give it a try. That seems like quite a bit of ashwagandha are you taking the ksm-66 version or root powder? N -acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a mucolytic compound. Depression may negatively impact your health and your hair If you wonder if working remotely can increase your chances of depression, or worsen your symptoms, here's what experts say and what to do about it. It is known for its role in modulating oxidative stress and several pathophysiological processes, such as apoptosis, inflammation, mitochondrial dysfunction, and neurotransmission. Do you mean N-acetyl cysteine (NAC)? I've bought supplement doses for energy support. Trusted by business builders worldwide,. 1 and and 2), the enzyme that converts kynurenine into KYNA (Blanco-Ayala et al Taken together, these data suggest that NAC may help restore NMDAR neurotransmission, while guanfacine would strengthen that signal by closing K+ channels to strengthen PFC connections. NAC helps to fix the level of a brain chemical called glutamate. Theanine and Ashwaghanda are good for anxiety. Too much of a racetam can cause negative cognitive effects. We utilized random-effect analysis to evaluate. NAC significantly increased the Aβ plaque load in the cortex while the number of parenchymal amyloid deposits in the remaining brain areas including basal ganglia. NAC does NOT cause cancer. Horrible brain fog, depression and a very spaced out dissociated feeling. Resulting in less anxiety and depression. Caffeine stimulates the. Skip to main content. Lasted about a week or two after taking NAC for a few days. It helps repair the liver and as a result hangovers. Glycine: makes me emotional, anxious and depressed. So it makes you feel bad while you use it but after you stop your state becomes better. What are some of the grossest things that can happen on planes? Do you go barefoot on planes? Would you walk barefoot through. NAC helps to fix the level of a brain chemical called glutamate. You give a loading dose of 150mg/kg followed by 70 mg/kg. Here are nine deficiencies linked to depression. We would like to show you a description here but the site won’t allow us. Treatment with N-acetylcysteine (NAC) is believed to reduce the clinical symptoms among individuals with substance abuse or dependence. It's a sulfur donor so that makes sense why it works so well for detox [deleted] • 3 yr Yes, this happens to me like clockwork when I take NAC. Talk to your doctor first. It is usually taken in doses from 1000 to 2000 milligrams per day. Do you have a condition that makes you specifically want to use NAC? NAC makes the rebound so much worse. The general problem is that I suffer from mild to medium depression and whenever I want to do something about changing my situation, which is always stress-filled due to the years of procrastination, any bit of extra stress, like learning a new skill or solving problems, usually causes stress to spike to the point of brain fog and exhaustion. This effect must be substantial. ABSTRACT. Excess glutamate in your brain is toxic to brain cells affecting neuron health, cognition, memory and mood. NAC is also processed by the SUOX pathway so proper Molybdenum status is also important when using NAC. It took me about two weeks to pinpoint as I has just started an antimicrobial treatment for gut infections. That seems like quite a bit of ashwagandha are you taking the ksm-66 version or root powder? N -acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a mucolytic compound. Seems NAC is very hit or very big miss for a lot of people. Psychology Today: Health, Help, Happiness + Find a Therapist Depressive Symptoms and Mood Swings after Stopping NAC. It the main ecxitatory Neurotransmitter in the brain next to Dopamine. Noticeably relieved but did not eliminate problems with: general anxiety, depressive-symptoms, irritability, mood, rumination, mental fluidity, etc. Most of them are positive and also regulated - test subjects with normal glutathione levels didn't experience an increase when supplementing, only test subjects with depleted levels - but you could certainly have. My short experience on NAC has been very positive, with similar experience to many of the posters here: improved mood,reduced anxiety. Inversely, NAC has been shown to decrease glutamatergic activity in these parts of the brain by reducing glutamate levels. My current brand of NAC actually recommends taking it with a protein containing meal Some people have sensitive cholinergic pathways and Alpha GPC is too much and can overload those pathways causing brain fog or full on depression (does go away after a little while though) I know there are a few anecdotes of NAC causing a sort of anhedonia even after even stopping chronic usage for a week or two. Excessive caffeine consumption can cause tingling in the hands as well as difficulty sleeping, fatigue, anger, depression and irritability, explains WebMD. Which Can also TEMPORARILY BE the symptoms as well. I suspect I spent between 5-10k in various supplements just to try and find something that worked We would like to show you a description here but the site won't allow us. Almost all my symptoms melted away. The transcription factor ∆FosB is one of the key proteins implicated in the gene expression changes in NAc caused by drugs of abuse, yet its effects on synaptic function in NAc MSNs are unknown. ADMIN MOD. Regarding the brain fog issue, I apologize if it seemed like I was suggesting mine was also caused by NAC. I have looked up things that can help and read NAC N-Acetyl-Cysteine is good for lowering paranoia symptoms. The thought is that it's due to increased histamine I still take it because I get so many benefits from NAC but I try to take as little as possible. Most of them are positive and also regulated - test subjects with normal glutathione levels didn't experience an increase when supplementing, only test subjects with depleted levels - but you could certainly have some genetic or nutritional. Which means, your VSS symptoms could get worse, as you need the hyper-activity. Jump to BlackBerry leaped as much as 8 Twitter Communities allows users to organize by their niche interest On Wednesday, Twitter announced Communities, a new feature letting users congregate around specific interests o. I would stop NAC immediately and keep taking agmatine, along with magnesium and l-Theanine as needed. Bill Nye the "Science Guy" got torn to pieces for his answer on Reddit. N-acetylcysteine (NAC) is a well-known and safe mucolytic agent, also used in patients with paracetamol overdose. NAC: after a few days of taking it, I start getting sinus headaches. Talk to your doctor first. You might be concerned about saying the wrong thing or pestering them with too many phone calls and texts Research indicates that some vitamin deficiencies may put you at a greater risk of depression. Just Google pink cloud so you are at least aware of what it is and what to look for. Reddit has been slowly rolling out two-factor authentication for beta testers, moderators and third-party app developers for a while now before making it available to everyone over. I take 3x500mg NAC (N-Acetyl-Cysteine) as I heard it helps liver, depression, anxiety and so much more. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. I used to take nac every day until I realized it was making phenibut give me intense anger and depression. The Associated Press is an independent global news organization dedicated to factual reporting. Get the Reddit app Scan this QR code to download the app now. It simply make cells growth faster, "good" cells and "bad" cells. Antidepressants helped me combat anxiety and depression symptoms but I never felt "content" (not happy, just okay) which I feel like isn't a lot to ask for. Apparently, this is a question people ask, and they don’t like it when you m. Fast food, alcohol, energy drinks, and. We would like to show you a description here but the site won't allow us. r/antidepressants A chip A close button A chip A close button Hey, it's 100% NAC beyond any reasonable doubt, it was the only noot I was taking at the time and the reacton started within 24h of the first dose. I've been taking this for at least 12 days now (with no issues). NAC supplements offer benefits such as helping the body create and use protective antioxidants. I'm a runner and if i take this before cross country i get extremely fatigued and have issues thinking. Zinc causing depression? Discussion I am ADHD, and have also struggled off and on with depression throughout my life. craigslist kansas city motorcycles for sale by owner I experimented with numerous supplements to alleviate my brain fog, and l-methylfolate was the only one that notably made a difference. Kava, lemonbalm, passion flower, california poppy, 100s of various supplements. But it makes me think about things less, it can make you tired as hell. On Tuesday, Reddit added the subreddi. Below I linked to an extensive video made by an expert. It might actually make you feel worse. It reduced my OCD 25% in the first week, and decreased my severe and severely treatment resistant depression also about 30%. I thought that NAC, working on the glutamate system, would be a good candidate for treating my symptoms as glutamate is often linked to both autism and anxiety/depression. You could try to dose sporadically or find the lowest effective dose for you if you want to minimise the risk of PAH. The estimated human dose for the rats 10-40mg/kg is 14mg/kg (or 217-435mg for a 150lb person) As for anxiolytic effects: Agmatine appears to be able to reduce anxiety at a dosage similar to that where depression is reduced, although there is a demonstratable bell curve with agmatine and double the dose does not have anxiolytic effects We would like to show you a description here but the site won’t allow us. You also don't need those extracts. arrialexa ago • Edited 8 yr You probably had some big glutathione imbalance or heavy metal toxicity that was causing your ADHD/depression symptoms that the NAC corrected. Glutamate causes an excited state, and it's used in memory and learning. NAD: causes headaches. NAC is used for tylenol overdoes and alcohol overdose. Welcome to the world of N-acetylcysteine, a disgusting compound typically administered with fruit juice, but still makes some people vomit. Recent studies have shown that N-acetyl cysteine (NAC), a glutamate modulator produces an antidepressant-like effect by normalization of the periterminal release of glutamate and/or antioxidant effects. noredink clever N-acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial. While social media can be a wonderful tool for bringing people together, it can sometimes cause damage in real life. Marilyn Monroe's Depression - Marilyn Monroe's depression heightened during the winter of 1960-61, causing her to be temporarily hospitalized. Same with NAC, it's been researched extensively way more than ashwagandha, tons of studies, it's often taken by copd and lung disease patients for years at high doses, used in mega doses to treat Tylenol toxicity, yet not a single report of depression or anhedonia, in fact again all studies on the mental health aspects of NAC are positive, with. Interesting. I found Nac helps my anxiety, but unbiquinol and nadh helped my energy more. On this sub, when it comes to NAC related. So NAC in powder form can have an unpleasant smell. you must first bring your chronically sore to remission. This seems to be at odds with most of the advice I've seen regarding choline supplementation. No recognizeable effects or changes either. I'm thinking of adding NAC, St John's Wort, B complex, and fish oil It mostly states how the patient was given diluted NAC in powder form. And I don’t say that in a rude or dismissive way either. The Great Depression caused many people to lose their sources of income and become impoverished. Research shows there m. I've been taking this for at least 12 days now (with no issues). southside villas This morning I tried 1500mg at once in the morning. Modification of NAc MSN synapses may occur in part via changes in the transcriptional potential of certain genes in a cell type–specific manner. In very high doses it has been shown to increase cancer risc by inhibiting senescence. I am on methylphenidate, buspirone and duloxetine. Sometimes when stopping drugs or alcohol you can develop intense feelings of euphoria, which can sometimes lead to relapse when they fade or you get too over confident. Sort by: welearntolive ago. Many potential mechanisms have been proposed to underlie the therapeutic effects. I take 3x500mg NAC (N-Acetyl-Cysteine) as I heard it helps liver, depression, anxiety and so much more. Mood dips Restlessness Frustration Lack of patience etc. I am unsure what causes them. Seems NAC is very hit or very big miss for a lot of people. I follow a low carb diet which already lowers glutamate levels After doing more research it seems that NAC causes this in quite a few people, I am going to take a. You need to augment treatment with more efficatious modalities, for example gold standard is clomipramine. But there’s no way 1 600mg pill can/would effect you that way or for this length of time. No side effects, but also no positive effects. It has a well-established safety profile, and its toxicity is uncommon and dependent on the route of administration and high dosages. Anyone find NAC helps their anxiety but makes depression worse? If so, has anyone found a way around this?. No year or country restrictions were used. Excessive caffeine consumption can cause tingling in the hands as well as difficulty sleeping, fatigue, anger, depression and irritability, explains WebMD. Many potential mechanisms have been proposed to underlie the therapeutic effects.
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The midpoint (optimum) can vary by, maybe, an order of magnitude between individuals. "Glutathione (GSH) is the most abundant cellular antioxidant. NAC causing HPA hyperactivity; magnolia bark can normalize HPA function. This can deplete selenium stores in the body leading to all kinds of issues, thyroid problems and brain fog among them. Oxtail soup is a pretty good one. those are (higher) level risk/reward Sometimes the simplest things can cause the most preferred. Why sarcosine is usually taken with NAC? I know that NAC has the function of increasing an endogenous antioxidant, glutathione. My anxiety and especially depression went way up. We would like to show you a description here but the site won't allow us. ADMIN MOD. I suffer from depression, anxiety and non-stop negative thought ruminations. Which Can also TEMPORARILY BE the symptoms as well. In addition to these effects, recent preclinical and clinical studies have shown that NAC exerts beneficial effects on different psychiatric disorders. I recently read an article suggesting that its best to cycle off NAC every once in a while to ensure that your body isn't building up a. i have started on tyrosine about 3 weeks ago. At first 500 mg/day. NAC lowers DAO and increases histamine. jamelizzzz free Kava, lemonbalm, passion flower, california poppy, 100s of various supplements. Added the Huberman stack for one day or Alpha GPC, L-tyrosine and garlic pills, and ALCAR of my own interest. Bill Nye the "Science Guy" got torn to pieces for his answer on Reddit. This morning I tried 1500mg at once in the morning. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Patients with Williams syndrome, a genetic disorder caused by a microdeletion in chromosome 7q11. I am slowly going back to normality, my anxiety is creeping back, today I took some l-tyrosine cause I thought NAC fucked up my dopamine in some way and now I'm feeling exactly like if I took NAC. Its remarkable antioxidant and anti-inflammatory capacity is the biochemical basis used to treat. 5-htp: makes me nauseous and depressed. 1 • 5 yr NAC's effects on glutamate levels are independent of its effects on GSH production. Antidepressants helped me combat anxiety and depression symptoms but I never felt "content" (not happy, just okay) which I feel like isn't a lot to ask for. The best evidence comes from a series of trials in which NAC improved symptoms of depression. These typically get worse with inhaling and occur within a small area. It simply make cells growth faster, "good" cells and "bad" cells. Since glutamate is excitatory, it'll decrease neuron excitation which results in a decrease in function. Yes, it does worsen my mood when I take it. Protip: take some DHA *1g/day true. No. Rebound from increased histamine could cause brain fog. Zinc causing depression? Discussion I am ADHD, and have also struggled off and on with depression throughout my life. Should I keep taking it or stop? I don't mind the loose bowels if it's a good thing and helping me detox, but if it was a detox symptom, I'd expect the effect to be strong when I first stsrt taking the supplement. houses for sale under 80000 near me Long term use and you will develop mineral imbalances. The Associated Press is an independent global news organization dedicated to factual reporting. Try chamomile tea for sleep. A 2016 study published in the Journal of Clinical Psychiatry looked at five double-blind, randomized, placebo-controlled studies of people using NAC for depression and found that the supplement appeared to improve symptoms of depression more than a placebo. It's being studied as treatment for some mental health conditions. NAC does NOT cause cancer. We would like to show you a description here but the site won't allow us. ADMIN MOD. Most of them are positive and also regulated - test subjects with normal glutathione levels didn't experience an increase when supplementing, only test subjects with depleted levels - but you could certainly have some genetic or nutritional. It also made me unease in a lot of (social) situations. WallStreetBets founder Jaime Rogozinski says social-media giant Reddit ousted him as moderator to take control of the meme-stock forum. r/StackAdvice A chip A close button A chip A close button People actually use NAC to make MDMA magical again because it helps heal the receptors. He has weighed the costs of pharm side effects with the cost of a set of mild symptoms. NAC is an amino acid, something present in many foods, but supplements give you a higher dose than you'd get in your daily diet. arrialexa ago • Edited 8 yr You probably had some big glutathione imbalance or heavy metal toxicity that was causing your ADHD/depression symptoms that the NAC corrected. I definitely noticed improvements in impulsive behavior and less anxiety and depression with 600mg NAC Works well for me. While there is no conclusive evidence of specific pathophysiology of depression, the National Center for Biotechnology Information suggests that the bodily stress of major depressi. NAC is too strong of an antioxidant because of how it works in bringing back cells marked for death, which includes tumors and cancerous cells NAC can also defeat athletic stress adaptation from exercise NAC blocks DAO enzyme which can cause histamine (mast-cell) reaction NAC can cause detrimental remodeling in heart and lungs Bavarian0 When you're hanging out with someone you genuinely like, but you're having a rough day - when they are joking around, even though you're really not feeling it, you still smile or chuckle. N-acetylcysteine (NAC) has been used as an antioxidant precursor to glutathione (γ-glutamylcysteinylglycine; GSH) in the treatment of paracetamol overdose for more than 30 years. We would like to show you a description here but the site won’t allow us. 24 hour daycare with transportation near me You also don't need those extracts. Results from six clinical trials suggest that treatment augmentation with NAC for bipolar depression appears to be superior to placebo, with a moderate effect size, but a large confidence interval. Nac is causing harsh stomach pain for about 10 minutes. dev has raised $11M to help software developers connect, share knowledge and discuss all that's happening across their ecosystems. It is usually taken in doses from 1000 to 2000 milligrams per day. Historical use of N-acetylcysteine. Start slow, get your body used to it and increase dosage if you are sensitive to the. NAC will disrupt glutamate homeostatis from the brain/nervous system. N-acetyl cysteine (NAC) is a conditionally essential amino acid. 23, commonly present with neuropsychiatric disorders []. Same with NAC, it's been researched extensively way more than ashwagandha, tons of studies, it's often taken by copd and lung disease patients for years at high doses, used in mega doses to treat Tylenol toxicity, yet not a single report of depression or anhedonia, in fact again all studies on the mental health aspects of NAC are positive, with. I was wondering if this is a common effect when taking NAC and if there are anythings I could be doing/ taking to mitigate this effect.
I read about it now more often that one should NOT take NAC daily. Horrible brain fog, depression and a very spaced out dissociated feeling. I notice good things from vitamin c on mood, but NAC did nothing in that regard just gave me more energy. Lithium is good tho 👍. This has kept my blood pressure normal even though L-tyrosine and NAC can cause hypertension in some people. These typically get worse with inhaling and occur within a small area. Increased depression on 600mg NAC : r/Nootropics - Reddit. I was wondering if this is a common effect when taking NAC and if there are anythings I could be doing/ taking to mitigate this effect. fake twin ultrasound Open navigation Go to Reddit Home. Glutamate causes an excited state, and it's used in memory and learning. This effect must be substantial. ABSTRACT. Taking about 1,800mg/day NAC, for at least a month, with a ~5 mg Lithium Orotate supplement. I've seen tens of reports about NAC causing depression in certain people, especially with agmatine use. And I don’t say that in a rude or dismissive way either. beauty room for rent perth nac would help for sure, it regulates/modulates dopamine receptors. it's also decreased the amount I struggle with hoarding issues. Data sources: A computerized literature search was conducted in MEDLINE, Embase, the Cochrane Library, SciELO, PsycINFO, Scopus, and Web of Knowledge. NAC is life changing for me. ssbbw gilf • N-acetyl-cysteine 600 mg daily often completely prevents my psychosis symptoms from manifesting. Overall the studies (including both bipolar and unipolar depression) found in favour of NAC as an adjunct for depressive symptoms. No year or country restrictions were used. Or check it out in the app stores. Also, NAC can reduce oxidative stress caused by glutamate over-excitation. gov/24612076/ Sort by: DrJeepers ago. Long term use and you will develop mineral imbalances. We would like to show you a description here but the site won't allow us.
arrialexa ago • Edited 8 yr You probably had some big glutathione imbalance or heavy metal toxicity that was causing your ADHD/depression symptoms that the NAC corrected. So you need a healthy balance between oxidative stress and antioxidant action to be good, which NAC can help. The risk for NAC promoting tumor growth/cancer is the same as any antioxidant because anti-oxidants fight oxidative stress, except you need some oxidative stress to fight against tumors and stuff like that. Here at Lifehacker, we are endlessly inundated with tips for how to live a more optimized life—but not all tips are created equal. L-theanine and lithium orotate have GABA increasing effects. My depression also is eased. But the connection has not been proven. If you already had normal glutathione levels (which is probably the case if you're young and otherwise healthy) then you could have been red-lining your glutathione levels with high doses of NAC. NAC helps to fix the level of a brain chemical called glutamate. Psychology Today: Health, Help, Happiness + Find a Therapist For people with bipolar disorder and depression, NAC may help decrease symptoms and improve quality of life. NAC chelating molybdenum and selenium, triggering a malfunction in the B-vitamin cycle and causing quick B12 deficiency similar how nitrous oxide does this. If you already have high levels, it makes sense NAC would make you feel poor. NAC significantly increased the Aβ plaque load in the cortex while the number of parenchymal amyloid deposits in the remaining brain areas including basal ganglia. Working remotely can feel overw. We know excess glutamate activity associates with psych symptoms. • Amiloride 5 mg once or twice daily— works very well. Why sarcosine is usually taken with NAC? I know that NAC has the function of increasing an endogenous antioxidant, glutathione. NAC is an amino acid, something present in many foods, but supplements give you a higher dose than you'd get in your daily diet. This sub in a nutshell shen_black A clear example of Placebo/nocebo effect. We would like to show you a description here but the site won’t allow us. Could have symptoms from that. domperidone lactation It may be beneficial for depression, schizophrenia, trichotillomania, and more. There was a post in another sub that said that he had taken NAC and that it improved his erection as nothing else had ever done. Large doses of zinc also do this to me skypieholeson. NAC depletes selenium. I also jus started on alpha lipoid acid, milk thistle, and lithium ortate- I had really bad stomach pains cause I was taking twice the recommended dosage from this study, along with what I listed, Co Q 10, Quarcetin, and handfuls of other supplements. Birth rates dropped because people could not afford to care for children, and divor. N-acetyl cysteine (NAC) is a conditionally essential amino acid. Cysteine contains a thiol (sulfur-hydrogen) group that kicks up mercury and other heavy metals (HMs). I'd like to hear from others that have experienced benefit from NAC. I am on methylphenidate, buspirone and duloxetine. I notice good things from vitamin c on mood, but NAC did nothing in that regard just gave me more energy. It is known for its role in modulating oxidative stress and several pathophysiological processes, such as apoptosis, inflammation, mitochondrial dysfunction, and neurotransmission. Try chamomile tea for sleep. clit jewelry While there is no conclusive evidence of specific pathophysiology of depression, the National Center for Biotechnology Information suggests that the bodily stress of major depressi. Is 1200mg nac and 1500mg ashwagandha 2x daily really needed to get the best results? I've been taking 300mg ksm-66 2x a day and jarrows nac 600mg sustain 2x a day. Excess glutamate in your brain is toxic to brain cells affecting neuron health, cognition, memory and mood. Kava, lemonbalm, passion flower, california poppy, 100s of various supplements. NAC (3 g day −1) did not altered specific OCD symptoms or depression severity, but it only reduced anxiety symptoms in patients with treatment-resistant OCD. It is usually taken in doses from 1000 to 2000 milligrams per day. Cysteine contains a thiol (sulfur-hydrogen) group that kicks up mercury and other heavy metals (HMs). But, nothing to uplift your dreaded existence in depression dungeon. arrialexa ago • Edited 8 yr You probably had some big glutathione imbalance or heavy metal toxicity that was causing your ADHD/depression symptoms that the NAC corrected. Business, Economics, and Finance. Taking any one of those make me feel brain fog, depression, anhedonia, confusion, twitchiness, anxiety, just generally awful. Our team has investigated NAC for a variety of disorders including MDD [17-20] Objective: To assess the utility of N-acetylcysteine administration for depressive symptoms in subjects with psychiatric conditions using a systematic review and meta-analysis. There's conflicting research but the way I've interpreted it is that high antioxidants can decrease your chance of getting cancer but once you have or have had cancer it can accelerate it. Which also NAC repairs Dopamine from ky research on it. Seems NAC is very hit or very big miss for a lot of people. Reddit is launching a new NFT-based avatar marketplace today that allows you to purchase blockchain-bas. N-Acetyl L-Cysteine (NAC) is the N-acetyl form of one of the naturally occurring amino acids of the body, L-Cysteine. Horrible brain fog, depression and a very spaced out dissociated feeling. I personally never had any issues with NAC and my sleeping habits. It's changing my life. InvestorPlace - Stock Market News, Stock Advice & Trading Tips Video games remain a scorching hot sector, attracting both big companies and s. I believe the effect is due to the circumstance that glutathione production is normally bottle necked by the amount of cysteine, but when you have excess cysteine due to NAC, the rate-limiting factor is the amount of glycine, and the cysteine activates NMDA receptors, leading to that dissociative anhedonia and depression. I'm thinking of adding NAC, St John's Wort, B complex, and fish oil It mostly states how the patient was given diluted NAC in powder form.